Best Research Topics In Medicinal Chemistry

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. 

Now-a-days, best research topics in  "Medicinal Chemistry" includes all relevant aspects of drug research given below. 

1. Pathobiochemistry of diseases

 

2. Identification and validation of (emerging) drug targets

3. Structural biology 

4. Druggability of targets

5. Drug design approaches, 

 

6. Chemogenomics

7. Synthetic chemistry including combinatorial methods

 

8. Bioorganic chemistry

9. Natural compounds

 

10. High-throughput screening 

11. Pharmacological in vitro and in vivo investigations

12. Drug-receptor interactions on the molecular level

 

13. Structure-activity relationships 

14. Drug absorption

 

15. Drug Distribution 

16. Metabolism and Elimination

 

17. Toxicology

18. Pharmacogenomics

Current Research Areas in Pharmaceutical Chemistry . . !!!

A pharmaceutical chemist is employed by a pharmaceutical, cosmetic, food, beverage or fragrance manufacturer. The job requires the chemist to assess the chemical and physical properties of a variety of natural and synthetic materials in an effort to investigate, understand and apply them to consumer and medicinal products.

 

Research in Pharmaceutical Chemistry currently encompasses a range of projects from the analytical to the biological in the broad areas of photobiology, drug design, molecular neuropharmacology, biomolecular action of drugs and identification of potential future drug targets.

  

Current Areas of  Pharmaceutical Research Focus include:

• Transcriptional and post-transcriptional regulation of cytokine and cell cycle protein gene expression.
• Mast cell and airway smooth muscle cell interactions in asthma.
• Herbal medicines as modulators of inflammation.
• Modulation of T-cell responses.
• Mechanisms of action of sphingosine 1-phosphate, a biologically active sphingolipid, on cell migration, growth and synthetic function.
• The role of calcium translocating ATPases responsible for regulating calcium levels in cells.
• The distribution and physiological function of a novel Ras-related G-protein in plasma membranes.
• Regulation of the VR1 vanilloid receptor in neuronal cells: effects of vanilloids.
• Investigation of the effects of calcium and drugs and, in particular, the role of magnesium-dependent ATPase in the control of phospholipid distribution.
• Investigation of the mechanism of transport of chemotherapeutic agents and the search for agents which can reverse multidrug resistance in cancer.
• Role of P-glycoprotein in regulation of drug levels.
• Development of agents which are to be released as the active anticancer drug by enzymes chemically linked to antibodies targeted to tumour cells.
• Purinergic receptors as potential targets for the treatment of leukemias and for inducing normal blood-cell maturation in the bone marrow.
• Targets of the inflammatory cascade.
• Membrane bound targets.
• G-protein coupled receptors.
• Schizophrenia targets.
• Studies towards the development of new therapeutic agents that act on GABA receptors and transporters for the treatment of brain disorders such as Alzheimer's disease and schizophrenia.
• Investigating the effects of natural and synthetic neurologically active agents on nicotinic receptors.
• Complementary structure-activity relationship studies of GABA and nicotinic receptors in order to understand the mechanisms of function as part of drug design & development.
• Isolation, identification and evaluation of bioactive natural products.
• Structure-activity relationship studies of natural products and synthetic analogues as part of the development of new medicinal agents.
• Liquid chromatography.
• Mass spectrometry.
• Instrumental thin-layer chromatography.
• Mechanism of action and active components of popular herbal medicines for management of diabetics.
• Immunomodulation and active components pf popular herbal medicines for cancer management.
• Pharmacognosy standardization, characterization, quantitative analysis of herbal medicines such as Echinacea, and propolis with HPTLC and HPLC.
• he development of drugs to treat memory deficits in disorders such as Alzheimer's Disease and Schizophrenia.
• Design and development of GABA-C selective ligands.
• Assessment of the effects of chemicals in the diet and herbal medicines e.g. flavonoids on GABA receptors.
• Factors influencing the stability of the antibiotics in the liquid and frozen states.
• Kinetics of rate of reactions of β lactam penicillins that undergo autocatalytic degradation.
• Analysis of herbal products and evaluation of their therapeutic values.